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CA-125 was initially detected using the murine monoclonal antibody designated OC125. Robert Bast , Robert Knapp and their research team first isolated this monoclonal antibody in 1981. [ 28 ] The protein was named "cancer antigen 125" because OC125 was the 125th antibody produced against the ovarian cancer cell line that was being studied.
However, treatment based only on elevated CA-125 levels and not any symptoms can increase side effects without any prolongation of life, so the implication of the outcome of a CA-125 test can be discussed before taking it. [122] The recommendation as of 2014 is recurrent cancer may be present if the CA-125 level is twice normal. [28]
A tumor marker is a biomarker that can be used to indicate the presence of cancer or the behavior of cancers (measure progression or response to therapy). They can be found in bodily fluids or tissue. Markers can help with assessing prognosis, surveilling patients after surgical removal of tumors, and even predicting drug-response and monitor ...
When a Ca 2+ influx occurs, cross bridges form between myosin and actin leading to the contraction of the muscle fibers. Influxes may occur from extracellular Ca 2+ diffusion via ion channels. This can lead to three different results. The first is a uniform increase in the Ca 2+ concentration throughout the cell. This is responsible for ...
The tumor marker CA-125 is frequently elevated in endometrial cancer and can be used to monitor response to treatment, particularly in serous cell cancer or advanced disease. [ 32 ] [ 44 ] [ 82 ] Periodic MRIs or CT scans may be recommended in advanced disease and women with a history of endometrial cancer should receive more frequent pelvic ...
It took more than five years, but the Dow Jones Industrial Average finally made up all the ground it lost in the financial crisis, surging to close at an all-time high today. China's announcement ...
Today marks the 125th birthday of Paris's Eiffel Tower.Erected for the 1889 World's Fair, Gustave Eiffel's controversial 324-meter structure (the tallest manmade object in the world at the time ...
If kidney impairment occurs as a result, manifestations can include increased urination, urination at night, and increased thirst. [6] Psychiatric manifestation can include emotional instability, confusion, delirium, psychosis, and stupor. [6] Calcium deposits known as limbus sign may be visible in the eyes. [7]