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Mammalian cochlear hair cells are of two anatomically and functionally distinct types, known as outer, and inner hair cells. Damage to these hair cells results in decreased hearing sensitivity, and because the inner ear hair cells cannot regenerate, this damage is permanent. [4] Damage to hair cells can cause damage to the vestibular system and ...
Hensen's cells are important in ion metabolism and homeostasis regulation of both endolymph and perilymph, modulation of the hearing sensitivity, regulation and regeneration of the hair cells, and prevention of the cochlea damage. [6] The outer hair cells of the cochlea preprocess the signal by active movements, which can be elevated by ...
They are thought to damage the hair cells of the cochlea. Long-term exposure to these drugs may cause damage that progresses to the upper turn of the cochlea, impairing hearing or even causing deafness. [6] Glycopeptides, on the other hand, are rarely associated with ototoxicity.
The drug is understood to damage multiple regions of the cochlea, causing the death of outer hair cells, as well as damage to the spiral ganglion neurons and cells of the stria vascularis. [27] Long-term retention of cisplatin in the cochlea may contribute to the drug's cochleotoxic potential. [28]
Proliferating supporting cells can acquire hair cell fate in mitotic division. The mouse's neonatal supporting cells proliferate after hair cell death and regenerate hair cells after damage. [26] The neonatal cochlea is resistant to hair cell damage caused by exposure to noise or drugs, which are toxic to the cochlea, or auditory nerve, in vivo ...
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Head and neck cancer is a general term encompassing multiple cancers that can develop in the head and neck region. These include cancers of the mouth, tongue, gums and lips (oral cancer), voice box (), throat (nasopharyngeal, oropharyngeal, [1] hypopharyngeal), salivary glands, nose and sinuses.
Oral cancer, also known as oral cavity cancer, tongue cancer or mouth cancer, is a cancer of the lining of the lips, mouth, or upper throat. [6] In the mouth, it most commonly starts as a painless red or white patch , that thickens, gets ulcerated and continues to grow.