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HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.
In 1986 Axel Ullrich, a German scientist working at Genentech, first discovered the Her-2 protein and gave a conference about it in which Slamon was present.Afterwards Slamon proposed to work together, since he suspected that a mutation in Her-2 might cause cancer, eventually they found a kind of aggressive breast cancer with a mutation in the gene responsible for the Her-2 protein and started ...
Year of discovery Name of the drug Year when the synthesis mechanism was developed Year that was Patented Governmental approval Patented expired 1901: Adrenaline: Jōkichi Takamine, 1901: 1901: 1901: N/A (Natural Hormone) 1906: Oxytocin: Discovered by Henry Hallett Dale, synthesized by Vincent du Vigneaud in 1952: 1925: 1926: N/A (Natural ...
The full HERC2 gene is located at 15q13, encoded by 93 exons and its transcription is under the control of a CpG rich promoter.This region on chromosome 15 is susceptible to breaks during chromosomal rearrangement and there are at least 12 partial duplicates of HERC2 between 15q11–15q13.
The threshold level for hormone receptor positivity was changed in 2010 and now requires more than 1% positive tumor nuclei are found in the tumor sample. [14] Newer techniques for categorising breast cancer are based on gene expression in the tumor which classifies breast cancer into: [15] [16] luminal A (HR+/HER2-) 68%; luminal B (HR+/HER2+) 10%
Image credits: woodenman22 #5. Around 11-13 years ago a male colleague showed up to our fancy ball in a dress, long wig, full face of makeup. No one knew if he did drag previously or anything, it ...
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