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A second version of the central dogma is popular but incorrect. This is the simplistic DNA → RNA → protein pathway published by James Watson in the first edition of The Molecular Biology of the Gene (1965). Watson's version differs from Crick's because Watson describes a two-step (DNA → RNA and RNA → protein) process as the central ...
A diagram of the central dogma of molecular biology circa 1958, as reconstructed by Francis Crick in "Central Dogma of Molecular Biology", Nature, vol. 227, pp. 561 ...
By 1945, Beadle, Tatum and others, working with Neurospora and other model organisms such as E. coli, had produced considerable experimental evidence that each step in a metabolic pathway is controlled by a single gene. In a 1945 review, Beadle suggested that "the gene can be visualized as directing the final configuration of a protein molecule ...
This image shows an example of the central dogma using a DNA strand being transcribed then translated and showing important enzymes used in the processes. The central dogma plays a key role in the study of molecular genetics. The central dogma states that DNA replicates itself, DNA is transcribed into RNA, and RNA is translated into proteins. [24]
The pathway from DNA to protein expression fundamental to the central dogma of biology. [2] In 1956, Francis Crick proposed what is now known as the "central dogma" of biology: [3] DNA encodes the genetic information required for an organism to carry out its life cycle. In effect, DNA serves as the "hard drive" which stores genetic data.
All of these processes form part of the central dogma of molecular biology, which describes the flow of genetic information in a biological system. As in DNA , genetic information in mRNA is contained in the sequence of nucleotides , which are arranged into codons consisting of three ribonucleotides each.
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