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Chromium(III) picolinate (also trivalent chromium) is a chemical compound with the formula Cr(C 5 H 4 N(CO 2)) 3, commonly abbreviated as CrPic 3. It is a bright-red coordination compound derived from chromium (III) and picolinic acid .
Trivalent chromium, or chromium(III), is an essential trace mineral in the human diet. [3] In some nutritional supplements, chromium(III) occurs as chromium(III) picolinate (in which chromium is bound to picolinic acid) or chromium(III) nicotinate (in which chromium is bound to nicotinic acid). Nicotinic acid is also known as the B vitamin niacin.
Chromium picolinate is the form of chromium found in most over-the-counter supplements, and it's been used to help manage blood sugar levels in people with pre-diabetes, insulin resistance, or ...
Chromium deficiency is described as the consequence of an insufficient dietary intake of the mineral chromium. Chromium was first proposed as an essential element for normal glucose metabolism in 1959, [ 1 ] but its biological function has not been identified. [ 2 ]
Structure of Zn(picolinate) 2 (H 2 O) 2. Hydrogenation of picolinic acid gives piperidine-2-carboxylic acid, a precursor to the drug Mepivacaine. Picolinic acid is a bidentate chelating agent of elements such as chromium, zinc, manganese, copper, iron, and molybdenum in the human body. [5] [6] It is a substrate in the Mitsunobu reaction.
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In 2005, the U.S. Food and Drug Administration had approved a qualified health claim for chromium picolinate with a requirement for specific label wording: "One small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes.
An alarming study that had Americans tossing out their black plastic kitchen utensils, toys and to-go packages earlier this month overstated the concern, the researchers admit.