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Similarly, "disease-free survival" is the length of time after patients have received treatment and have no detectable disease. Time to progression (TTP) does not count patients who die from other causes but is otherwise a close equivalent to PFS (unless there are many such events). [2] The FDA gives separate definitions and prefers PFS. [3]
Time- to- progression (TTP) was the primary efficacy endpoint. [24] Overall survival (OS), progression-free survival (PFS), and response rate (RR) were secondary endpoints. [24] Eligible people were age > 65 years. [24] A total of 682 people were randomized: 338 to receive MP and 344 to the combination of bortezomib plus MP. [24]
Radioembolization with 90 Y significantly prolongs time-to-progression (TTP) of HCC, [13] has a tolerable adverse event profile, and improves patient quality of life more than do similar therapies. [14] 90 Y has also found uses in tumor diagnosis by imaging the Bremsstrahlung radiation released by the microspheres. [15]
Patients receiving a placebo were offered to switch to sunitinib at that time. In the primary endpoint of the study, the median time to tumor progression (TTP) was more than four-fold longer with sunitinib (27 weeks) compared with placebo (six weeks, P<.0001), based on an independent radiological
Tumor response rate was the primary endpoint using Response Evaluation Criteria In Solid Tumors (RECIST) criteria, while time to progression (TTP), progression free survival (PFS) and overall survival (OS) were defined as the secondary endpoints. In this study, no significant difference between the groups was noted and both groups showed ...
An example of a Kaplan–Meier plot for two conditions associated with patient survival. The Kaplan–Meier estimator, [1] [2] also known as the product limit estimator, is a non-parametric statistic used to estimate the survival function from lifetime data.
Whip up this goat cheese–tomato toast to enjoy the fresh flavors of summer any time of the year. This sweet-and-savory combo makes a perfect breakfast, lunch or snack. For an extra burst of ...
Slower time resolution allows more detailed images, but may limit interpretation to only looking at signal intensity curve shape. In general, persistent increased signal intensity (corresponding to decreased T1 and thus increased Gd interaction) in a DCE-MRI image voxel indicates permeable blood vessels characteristic of tumor tissue, where Gd ...
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