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Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
Oral phenylephrine is ineffective and “should almost never be used,” said Dr. Purvi Parikh, an allergist and immunologist at Allergy & Asthma Associates of Murray Hill in New York City.
The concern goes beyond ineffectiveness; phenylephrine can come with side effects such as headaches, insomnia and nervousness. At higher doses, it can increase blood pressure.
Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists. The effects are not limited to the nose, and these medicines may cause hypertension (high blood pressure) through vasoconstriction; it is for this reason that people with hypertension are advised to avoid them. Most ...
Phenylephrine is the main ingredient used in many common over-the-counter congestion products. It is safe to use, but an independent advisory committee to the FDA agreed Tuesday that it is ...
Xylometazoline works by stimulating adrenergic receptors on the lamina propria of blood vessels in the nose. The decongestant effect is due to constriction of large veins in the nose which swell up during the inflammation of any infection or allergy of the nose.
Amirshahi noted that pseudoephedrine comes with side effects, including dizziness, nervousness and trouble sleeping. It may also increase blood pressure, a potential drawback for people with heart ...
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