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Molecular Therapy is a scientific journal, published by Cell Press, that aims to develop and explore "molecular and cellular therapeutics to correct genetic and acquired diseases". [ 1 ] The founder of the journal and its Editor-in-Chief in the first five years was Inder Verma .
The Journal publishes novel and innovative results from high quality scientific and clinical studies in the fields of cell and gene therapy. Cytotherapy publishes articles exploring the following topics: Development and/or characterization of novel gene therapies and cell and/or extracellular vesicle (EV)-based therapeutics.
Targeted Therapy Database (TTD) from the Melanoma Molecular Map Project ; Targeted therapy Fact sheet from the U.S. National Cancer Institute; Molecular Oncology: Receptor-Based Therapy Special issue of Journal of Clinical Oncology (April 10, 2005) dedicated to targeted therapies in cancer treatment
A more recent focus of the journal includes Cell Therapy, with genetic modification, in essence ex vivo gene therapy. Previous issues have focused on the latest developments in gene transfer, gene expression and regulation, development of novel gene delivery vectors, and ex vivo gene therapies, animal models, and human therapeutic applications.
Molecular oncology has identified genes that are involved in the development of cancer. The research combined diverse techniques ranging from genomics , computational biology , tumour imaging , in vitro and in vivo functional models to study biological and clinical phenotypes .
This facilitates the final step in generation and implementation of both autologous and allogeneic CAR-T cell therapy. While this delivery method is reliable for hematologic cancers, as demonstrated by successful clinical trials and FDA regulation, systemic delivery may result in an increase in autoimmune overload, leading to toxic disorders ...
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Targeted therapy of lung cancer refers to using agents specifically designed to selectively target molecular pathways responsible for, or that substantially drive, the malignant phenotype of lung cancer cells, and as a consequence of this (relative) selectivity, cause fewer toxic effects on normal cells.