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The leading cause of hyperglycemia in type 2 diabetes is the failure of insulin to suppress glucose production by glycolysis and gluconeogenesis due to insulin resistance. [39] Insulin normally inhibits glycogenolysis, but fails to do so in a condition of insulin resistance, resulting in increased glucose production. [40]
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
The proliferative variety is dangerous and often leads to blindness. It has been the leading non0traumatic cause of blindness in adults in the developed world for much of the 20th century. Diabetogenic Causing diabetes; some drugs cause blood glucose (sugar) to rise temporarily. Other cause it to rise permanently; if so they have caused diabetes.
Moreover, certain medications prescribed for different conditions have the potential to cause HHS. [13] [15] As with DKA, urgent medical treatment is necessary, commonly beginning with fluid volume replacement. [8] On the whole, HHS is a medical emergency marked with hyperglycemia, hyperosmolarity, dehydration, and mild or no ketosis. [15]
Some researchers believe glucagon dysregulation to be the primary cause of early stage hyperglycemia. [82] Leading hypotheses for the cause of postprandial hyperglucagonemia suggest that exogenous insulin therapy is inadequate to replace the lost intraislet signalling to alpha cells previously mediated by beta cell-derived pulsatile insulin ...
There are a number of medications and other health problems that can predispose to diabetes. [50] Some of the medications include: glucocorticoids, thiazides, beta blockers, atypical antipsychotics, [51] and statins. [52] Those who have previously had gestational diabetes are at a higher risk of developing type 2 diabetes. [24]
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