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Array slicing. In computer programming, array slicing is an operation that extracts a subset of elements from an array and packages them as another array, possibly in a different dimension from the original. Common examples of array slicing are extracting a substring from a string of characters, the " ell " in "h ell o", extracting a row or ...
The major spliceosome splices introns containing GU at the 5' splice site and AG at the 3' splice site. It is composed of the U1 , U2 , U4 , U5 , and U6 snRNPs and is active in the nucleus. In addition, a number of proteins including U2 small nuclear RNA auxiliary factor 1 (U2AF35), U2AF2 (U2AF65) [ 10 ] and SF1 are required for the assembly of ...
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to produce different splice variants. For example, some exons of a gene may be included within or excluded from the final RNA product of the gene. [1]
A cut splice is a join between two ropes, made by side splicing the ends slightly apart, to make an eye in the joined rope which lies shut when the rope is taut. Its original name was bowdlerised to "cut splice". A line eye-spliced to a snap shackle. Eye splice – A splice where the working end is spliced into the working part forming a loop.
Minigenes have been applied to the study of a diverse array of genetic diseases due to the aforementioned abundance of alternatively spliced genes and the specificity and variation observed in splicing regulation. [1] [2] [12] The following are examples of minigene use in various diseases. While it is not an exhaustive list, it does provide a ...
Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). [1] It consists of two steps: the first step is to select only the subset of DNA that encodes proteins. These regions are known as exons —humans have about 180,000 ...
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA ...
These include the 5' end splice site, the branch point sequence, the polypyrimidine tract, and the 3' end splice site. The spliceosome catalyzes the removal of introns, and the ligation of the flanking exons. [citation needed] Introns typically have a GU nucleotide sequence at the 5' end splice site, and an AG at the 3' end splice site.