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Phentermine is an norepinephrine and dopamine releasing agent (NDRA) and produces stimulant, rewarding, and appetite suppressant effects. [8] [9] [10] Chemically, it is a substituted amphetamine. [11] Phentermine was approved for medical use in the United States in 1959. [3] It is available as a generic medication. [3]
Originally available only by prescription, it was approved by the FDA for over-the-counter sale in February 2007. [32] In May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety information about rare cases of severe liver injury that have been reported with the use of this medication. [ 33 ]
Phentermine and topiramate was developed by Vivus, a California pharmaceutical company. In December 2009, Vivus, Inc. submitted a new drug application (NDA) to the FDA and on 1 March 2010, Vivus, Inc. announced that the FDA accepted the NDA for review.
A similar drug, aminorex, had caused severe lung damage and "provided reason to worry that similar drugs ... could increase the risk of a rare but often fatal lung disease, pulmonary hypertension." [ 1 ] In 1994, Wyeth official Fred Wilson expressed concerns about fenfluramine's labeling containing only four cases of pulmonary hypertension when ...
Rexall Pharmacy Group ULC is a chain of retail pharmacies in Canada. Founded in 1904, Rexall has almost 400 pharmacies across Canada with 8,000 employees. Founded in 1904, Rexall has almost 400 pharmacies across Canada with 8,000 employees.
Arbor Drugs (acquired by CVS in 1998) Big B Drugs (acquired by Revco in 1996; rebranded as CVS in 1997) Brooks Pharmacy (acquired by Rite Aid in 2007) Cunningham Drug (acquired by Walgreens in 1991) Dart Drug (bankrupt in 1990) Drug Emporium; Drug Fair (company liquidated in 2009, assets purchased by Walgreens) Eckerd (acquired by Rite Aid in 2007)