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Primidone is not indicated for essential tremor but is often used as a first-line therapy for essential tremor, as is propranolol. In tremor amplitude reduction, it is just as effective as propranolol, reducing it by 50%. Both drugs are well studied for this condition, unlike other therapies, and are recommended for initial treatment.
Primidone is an anticonvulsant which metabolized into phenobarbital and phenylethymalnonamide. [36] This medication has shown the same beneficial effects in reducing tremors as propranolol and is recommended for use based on guidelines from the American Academy of Neurology and the MDS Task Force on Tremor.
Propranolol was patented in 1962 and approved for medical use in 1964. [9] It is on the World Health Organization's List of Essential Medicines. [10] Propranolol is available as a generic medication. [2] In 2022, it was the 77th most commonly prescribed medication in the United States, with more than 8 million prescriptions. [11] [12]
Intention tremors that are caused by normal, everyday activities, such as stress, anxiety, fear, anger, caffeine, and fatigue, do not seem to result from damage to any part of the brain. These tremors, instead, seem to be a temporary worsening of a small tremor that is present in every human being. These tremors generally go away with time. [5]
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Essential tremor may be treated with beta blockers (such as propranolol and nadolol) or primidone, an anticonvulsant Cerebellar tremor symptoms may decrease with the application of alcohol (ethanol) or benzodiazepine medications, both of which carry some risk of dependence or addiction
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