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The main metabolite excreted in the urine is 11-Nor-9-carboxy-THC, also known as THC-COOH. Most cannabis drug tests yield a positive result when the concentration of THC-COOH in urine exceeds 50 ng/mL. [10] Urine testing is an immunoassay based test on the principle of competitive binding. Drugs which may be present in the urine specimen ...
The main metabolite in urine is the ester of glucuronic acid and 11-OH-THC and free THC-COOH. In the feces, mainly 11-OH-THC was detected. [37] Estimates of the elimination half-life of THC are variable. [23] THC was reported to have a fast initial half-life of 6 minutes and a long terminal half-life of 22 hours in a population pharmacokinetic ...
Δ-8-tetrahydrocannabinol (delta-8-THC, [a] Δ 8-THC) is a psychoactive cannabinoid found in the cannabis plant. [1] It is an isomer of delta-9-tetrahydrocannabinol (delta-9-THC, Δ 9-THC), the compound commonly known as THC, with which it co-occurs in hemp; natural quantities of ∆ 8-THC found in hemp are low.
These are achieved at lower doses, because many synthetic cannabinoids are more potent than marijuana, and users are often unaware of exactly what they are getting and how potent it is. [62] For example, Δ 9-THC has an EC 50 of 250 nM at CB 1 and 1157 nM at CB 2, whereas PB-22 has an EC 50 of 5.1 nM at CB 1 and 37 nM at CB 2. [8]
Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), an active component of cannabis. [1]THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked or cooked into cannabis edibles.
Despite the CBD and THC having the same molecular weight, multiple analytical methods are able to differentiate them. [11] "on the recovery of both THC (86.7−90.0%) and CBD (92.3−95.6%). The slightly lower recovery of THC can be explained by the fact that THC is less polar than CBD and more likely to remain in the nonpolar sunflower oil." [11]
Heavy metal detox, or detoxification, is the removal of toxic heavy metal substances from the body. In conventional medicine, detoxification can also be achieved artificially by techniques such as dialysis and (in a very limited number of cases) chelation therapy.
] Detox diets are often high in fiber. Proponents claim that this causes the body to burn accumulated stored fats, releasing fat-stored "toxins" into the blood, which can then be eliminated through the blood, skin, urine, feces and breath. Proponents claim that things such as an altered body-odor support the notion that detox diets have an effect.