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  2. Polymerase chain reaction - Wikipedia

    en.wikipedia.org/wiki/Polymerase_chain_reaction

    A strip of eight PCR tubes, each containing a 100 μL reaction mixture Placing a strip of eight PCR tubes into a thermal cycler. The polymerase chain reaction (PCR) is a method widely used to make millions to billions of copies of a specific DNA sample rapidly, allowing scientists to amplify a very small sample of DNA (or a part of it) sufficiently to enable detailed study.

  3. Amplified fragment length polymorphism - Wikipedia

    en.wikipedia.org/wiki/Amplified_fragment_length...

    Amplified fragment length polymorphism (AFLP-PCR or AFLP) is a PCR-based tool used in genetics research, DNA fingerprinting, and in the practice of genetic engineering. Developed in the early 1990s by Pieter Vos, [1] AFLP uses restriction enzymes to digest genomic DNA, followed by ligation of adaptors to the sticky ends of the restriction ...

  4. Reverse transcription polymerase chain reaction - Wikipedia

    en.wikipedia.org/wiki/Reverse_transcription...

    RT-PCR. Reverse transcription polymerase chain reaction (RT-PCR) is a laboratory technique combining reverse transcription of RNA into DNA (in this context called complementary DNA or cDNA) and amplification of specific DNA targets using polymerase chain reaction (PCR). [1] It is primarily used to measure the amount of a specific RNA.

  5. Variants of PCR - Wikipedia

    en.wikipedia.org/wiki/Variants_of_PCR

    This method is deployed for DNA sequencing, genome walking, and DNA footprinting. [12] A related technique is amplified fragment length polymorphism, which generates diagnostic fragments of a genome. Methylation-specific PCR (MSP) is used to identify patterns of DNA methylation at cytosine-guanine (CpG) islands in genomic DNA. [13]

  6. Hi-C (genomic analysis technique) - Wikipedia

    en.wikipedia.org/wiki/Hi-C_(genomic_analysis...

    [4] [16] The ideal range of PCR cycles is 9–15 and it is more ideal to pool multiple PCR reactions to get enough DNA for sequencing, than to increase the number of cycles for one PCR reaction. [4] [16] The PCR products are purified again using AMPure beads to remove primer dimers and then quantified before being sequenced.

  7. Inverse polymerase chain reaction - Wikipedia

    en.wikipedia.org/wiki/Inverse_polymerase_chain...

    Inverse polymerase chain reaction (Inverse PCR) is a variant of the polymerase chain reaction that is used to amplify DNA with only one known sequence. One limitation of conventional PCR is that it requires primers complementary to both termini of the target DNA, but this method allows PCR to be carried out even if only one sequence is ...

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