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Spread from the skin is unusual, and the prognosis is excellent [2]: 218 with a 5-year survival of over 97%. [2]: 314 The International Extranodal Lymphoma Study Group identified elevated LDH, more than two skin lesions, and nodular lesions as three prognostic factors, that are used to assess a cutaneous lymphoma international prognostic index (CLIPI), which is prognostic of disease-free status.
In situ follicular lymphoma is an accumulation of monoclonal B cells (i.e. cells descendent from a single ancestral cell) in the germinal centers of lymphoid tissue. These cells commonly bear a pathological genomic abnormality, i.e. a translocation between position 32 on the long (i.e. "q") arm of chromosome 14 and position 21 on chromosome 18's q arm.
Localized or more generalized skin symptoms, generally indolent, in a more aggressive variant, Sézary's disease, skin erythema and peripheral blood involvement. Primary cutaneous CD30-positive T-cell lymphoproliferative disorders Primary cutaneous anaplastic large cell lymphoma; Lymphomatoid papulosis; Peripheral T-cell lymphoma not otherwise ...
Basal cell carcinoma (BCC): As the most common type of skin cancer, BCC accounts for 80% of all skin cancer diagnoses in the U.S., per AAD. Typically, BCC looks like a skin-colored, translucent ...
Symptoms can include swollen but painless lymph nodes, unexplained fever, and unintended weight loss. [2] There are several subtypes, the most common of which is follicular lymphoma. Others include cutaneous T-cell lymphoma, marginal zone lymphoma, chronic lymphocytic leukemia, and Waldenström macroglobulinemia. [2]
The use of rituximab has been established for the treatment of B-cell–derived hematologic malignancies, including follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). [ 7 ] In addition to cure-directed treatment, people can benefit from self-care to manage symptoms.
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