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Copy number analysis is the process of analyzing data produced by a test for DNA copy number variation in an organism's sample. One application of such analysis is the detection of chromosomal copy number variation that may cause or may increase risks of various critical disorders.
Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals. [1] Copy number variation is a type of structural variation: specifically, it is a type of duplication or deletion event that affects a considerable number of base pairs. [2]
Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair. [1] It detects copy number changes at the molecular level, and software programs are used for analysis.
Array CGH has proven to be a specific, sensitive, fast and high-throughput technique, with considerable advantages compared to other methods used for the analysis of DNA copy number changes making it more amenable to diagnostic applications. Using this method, copy number changes at a level of 5–10 kilobases of DNA sequences can be detected. [15]
The step detection problem occurs in multiple scientific and engineering contexts, for example in statistical process control [1] (the control chart being the most directly related method), in exploration geophysics (where the problem is to segment a well-log recording into stratigraphic zones [2]), in genetics (the problem of separating ...
This closed-loop gain is of the same form as the open-loop gain: a one-pole filter. Its step response is of the same form: an exponential decay toward the new equilibrium value. But the time constant of the closed-loop step function is τ / (1 + β A 0), so it is faster than the forward amplifier's response by a factor of 1 + β A 0:
There is a simple constructive method to create arbitrarily long complementary sequences. For the case of cyclic autocorrelation, other sequences have the same property of having perfect (and uniform) sidelobes, such as prime-length Legendre sequences , Zadoff–Chu sequences (used in 3rd- and 4th-generation cellular radio) and 2 n − 1 ...
A gain greater than one (greater than zero dB), that is, amplification, is the defining property of an active device or circuit, while a passive circuit will have a gain of less than one. [4] The term gain alone is ambiguous, and can refer to the ratio of output to input voltage (voltage gain), current (current gain) or electric power (power ...