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Bipolar disorder is a serious mental health condition affecting 2.8 percent of adults in the United States. It involves episodes of mania (extreme highs) and depression (intense lows).
In a single controlled study of twenty one patients, the dopamine D 3 receptor agonist pramipexole was found to be highly effective in the treatment of bipolar depression. Treatment was initiated at 0.125 mg thrice daily and increased at a rate of 0.125 mg thrice daily to a limit of 4.5 mg per day until the patients' condition satisfactorily ...
The poor response from some bipolar patients to treatment has given evidence to the concept of treatment-resistant bipolar disorder. [ 163 ] [ 164 ] Guidelines to the definition of treatment-resistant bipolar disorder and evidence-based options for its management were reviewed in 2020.
IPSRT was studied as one of three intensive psychosocial treatments in the NIMH-funded Systematic Treatment Enhancement Program for Bipolar Disorder [18] (STEP-BD). STEP-BD was a long-term outpatient study investigating the benefits of psychotherapies in conjunction with pharmacotherapy in treating episodes of depression and mania, as well as ...
The global estimated lifetime prevalence of bipolar disorder among adults range from 1 to 3 percent. [63] The annual incidence is estimated to vary from 0.3 to 1.2 percent worldwide. [ 23 ] According to the World Mental Health Survey Initiative, the lifetime prevalence of BP-II was found to be 0.4%, with a 12-month prevalence of 0.3%. [ 64 ]
They note that about 30% of people with depression do not adequately respond to treatment. They say the subtypes may help identify potential treatment responses for things such as antidepressants ...
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