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Tricyclic antidepressants (TCAs) ... fibromyalgia and chronic musculoskeletal pain. It’s also prescribed off-label for stress urinary incontinence and chemotherapy-induced peripheral neuropathy ...
For most people with fibromyalgia, the potential benefits of treatment with the serotonin and norepinephrine reuptake inhibitors duloxetine and milnacipran and the tricyclic antidepressants, such as amitriptyline, are outweighed by significant adverse effects (more adverse effects than benefits), however, a small number of people may experience ...
The TCAs show efficacy in the clinical treatment of a number of different types of chronic pain, notably neuralgia or neuropathic pain and fibromyalgia. [ 17 ] [ 18 ] The precise mechanism of action in explanation of their analgesic efficacy is unclear, but it is thought that they indirectly modulate the opioid system in the brain downstream ...
Duloxetine, tricyclic antidepressants, and anticonvulsants have similar tolerability while opioids cause more side effects. [34] Another review in Prescrire International considered the moderate pain relief achieved with duloxetine to be clinically insignificant and the results of the clinical trials unconvincing.
Unlike other antidepressants, bupropion is known to cause fewer and less severe adverse symptoms, like drowsiness, weight loss, weight gain and intimate dysfunction.
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