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Statins appear to be effective at preventing cardiovascular disease and death in older adults, according to new research. Most clinical trials evaluating statins have not included people 75 and ...
Overall, our findings suggest that more people over 70 years of age should be considered for statin treatment.” — Borislava Mihaylova, DPhil “Cardiovascular disease remains a leading cause ...
In a Cochrane systematic review the dose-related magnitude of atorvastatin on blood lipids was determined. Over the dose range of 10 to 80 mg/day total cholesterol was reduced by 27.0% to 37.9%, LDL cholesterol by 37.1% to 51.7% and triglycerides by 18.0% to 28.3%. [103]
Over the dose range of 1 to 80 mg/day strong linear dose‐related effects were found; total cholesterol was reduced by 22.1% to 44.8%, LDL cholesterol by 31.2% to 61.2%, non-HDL cholesterol by 28.9% to 56.7% and triglycerides by 14.4% to 26.6%.
[2] [3] [4] Side effects of statins include muscle pain, increased risk of diabetes, and abnormal blood levels of certain liver enzymes. [5] Additionally, they have rare but severe adverse effects, particularly muscle damage, and very rarely rhabdomyolysis. [6] [7]
The researchers calculated that using PREVENT equations could also decrease the number of adults who meet eligibility criteria for primary prevention statin use from 45.4 million to 28.3 million.
[1] [2] The trial, which began in 2003, was directed by Paul Ridker of Brigham and Women's Hospital. [ 3 ] Because half of all vascular events occur in patients with normal or low levels of LDL cholesterol, JUPITER was designed to determine whether hs-CRP testing could identify these patients, and whether statin therapy could prevent ...
Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels. [4]