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Lamotrigine is metabolized predominantly by glucuronic acid conjugation. Its major metabolite is an inactive 2-n-glucuronide conjugate. [83] Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half ...
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Valproate is known to cause serious abnormalities or birth defects in the unborn child if taken during pregnancy, [7] [8] and is contra-indicated for women of childbearing age unless the drug is essential to their medical condition and the person is also prescribed a contraceptive.
Print/export Download as PDF; Printable version; In other projects ... Adverse effects by frequency for use of valproate semisodium. [1] [2] [3] Very common (>10% ...
ATC code N03 Antiepileptics is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
Combining lamotrigine with sodium valproate increases the risk of SJS. [26] Nonsteroidal anti-inflammatory drugs (NSAIDs) are a rare cause of SJS in adults; the risk is higher for older patients, women, and those initiating treatment. [27] Typically, the symptoms of drug-induced SJS arise within a week of starting the medication.
Women who intend to become pregnant should switch to a different medication if possible or decrease their dose of valproate. [23] Women who become pregnant while taking valproate should be warned that it causes birth defects and cognitive impairment in the newborn, especially at high doses (although valproate is sometimes the only drug that can ...
Among bipolar patients taking anticonvulsants, those on lamotrigine have a better cognitive profile than those on carbamazepine, valproate, topiramate, and zonisamide. [ 36 ] Although decreased verbal memory and slowed psychomotor speed are common side effects of lithium use [ 37 ] [ 38 ] these side effects usually disappear after ...