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Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants. TCAs were discovered in the early 1950s and were marketed later in the decade. [ 1 ] They are named after their chemical structure , which contains three rings of atoms .
Tricyclic antidepressants (TCAs) Tetracyclic antidepressants (TeCAs) Monoamine oxidase inhibitors (MAOIs) ... Serotonin–norepinephrine reuptake inhibitors, or SNRIs, are a common type of ...
The majority of the tricyclic antidepressants (TCAs) act primarily as serotonin–norepinephrine reuptake inhibitors (SNRIs) by blocking the serotonin transporter (SERT) and the norepinephrine transporter (NET), respectively, which results in an elevation of the synaptic concentrations of these neurotransmitters, and therefore an enhancement of ...
Toggle Norepinephrine–dopamine reuptake inhibitors (NDRIs) subsection. 8.1 Off-label only. ... Tricyclic antidepressants include: Amitriptyline (Elavil, Endep)
Serotonin-norepinephrine reuptake inhibitors (SNRIs). ... Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer ...
Actions of imipramine-like tricyclic antidepressants have complex, secondary adaptions to their initial and sustained actions as inhibitors of norepinephrine transport and variable blockade of serotonin transport. Norepinephrine interacts with postsynaptic α and β adrenergic receptor subtypes and presynaptic α 2 autoreceptors.
Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.
Maprotiline (Ludiomil) – can also be classified as a TCA and grouped with the secondary amines; Mianserin (Tolvon) Mirtazapine (Remeron) Setiptiline (Tecipul) Drugs that contain four rings not all fused together but are sometimes still classified as TeCAs include: Amoxapine (Asendin) – often classified as a TCA and grouped with the ...