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The parahippocampal gyrus (or hippocampal gyrus [1]) is a grey matter cortical region of the brain that surrounds the hippocampus and is part of the limbic system. The region plays an important role in memory encoding and retrieval. It has been involved in some cases of hippocampal sclerosis. [2] Asymmetry has been observed in schizophrenia. [3]
The uncus is an anterior extremity of the parahippocampal gyrus.It is separated from the apex of the temporal lobe by a sulcus called the rhinal sulcus. [1] Although superficially continuous with the hippocampal gyrus, the uncus forms morphologically a part of the rhinencephalon.
In human anatomy, the piriform cortex has been described as consisting of the cortical amygdala, uncus, and anterior parahippocampal gyrus. [1] More specifically, the human piriform cortex is located between the insula and the temporal lobe, anteriorly and laterally of the amygdala. [2] [3]
Area 27 of Brodmann-1909 is a cytoarchitecturally defined cortical area that is a rostral part of the parahippocampal gyrus.It is commonly regarded as a synonym of presubiculum.
View of left entorhinal cortex (red) from beneath the brain, with front of brain at top. Artist's rendering. The superficial layers – layers II and III – of EC project to the dentate gyrus and hippocampus: Layer II projects primarily to dentate gyrus and hippocampal region CA3; layer III projects primarily to hippocampal region CA1 and the subiculum.
Cross-section of cerebral hemisphere showing structure and location of hippocampus Coronal section of the brain of a macaque monkey, showing hippocampus (circled) The hippocampus is a five centimetre long ridge of gray matter tissue within the parahippocampal gyrus that can only be seen when the gyrus is opened up.
The PCC, together with the retrosplenial cortex, forms the retrosplenial gyrus. The posterior cingulate cortex is bordered by the following brain regions: the marginal ramus of the cingulate sulcus (superiorly), the corpus callosum (inferiorly), the parieto-occipital sulcus (posteriorly), and Brodmann area 24 (anteriorly). [4]
Visual areas TE and TEO send and receive a significant reciprocal connection with perirhinal cortex. Weaker, but still significant, projections come from other parahippocampal regions and from the superior temporal sulcus. Other inputs include anterior cingulate and insular regions, in addition to prefrontal projections.