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Just as immunogenic death of infected cells induces immune response to the infectious agent, immunogenic death of cancer cells can induce an effective antitumor immune response through activation of dendritic cells (DCs) and consequent activation of specific T cell response. [7] [6] This effect is used in antitumor therapy.
Brainstem death is a clinical syndrome defined by the absence of reflexes with pathways through the brainstem – the "stalk" of the brain, which connects the spinal cord to the mid-brain, cerebellum and cerebral hemispheres – in a deeply comatose, ventilator-dependent patient.
Overview of signal transduction pathways involved in apoptosis. Cell death is the event of a biological cell ceasing to carry out its functions. This may be the result of the natural process of old cells dying and being replaced by new ones, as in programmed cell death, or may result from factors such as diseases, localized injury, or the death of the organism of which the cells are part.
Brain death is used as an indicator of legal death in many jurisdictions, [6] but it is defined inconsistently and often confused by the public. [7] Various parts of the brain may keep functioning when others do not anymore, and the term "brain death" has been used to refer to various combinations.
The role of cell death is the maintenance of tissue and organ homeostasis, for example, the regular loss of skin cells or a more active role seen in involuting tissues like the thymus. Cells die either by accident or design. In fact there are two mechanisms of cell death; necrosis and apoptosis (apoptosis in invertebrates is called cell ...
In the human brain the brainstem is composed of the midbrain, the pons, and the medulla oblongata. [1] The midbrain is continuous with the thalamus of the diencephalon through the tentorial notch, and sometimes the diencephalon is included in the brainstem. [2] The brainstem is very small, making up around only 2.6 percent of the brain's total ...
Brain death refers to an irreversible total loss of brain function. [200] [201] This is characterised by coma, loss of reflexes, and apnoea, [200] however, the declaration of brain death varies geographically and is not always accepted. [201] In some countries there is also a defined syndrome of brainstem death. [202]
The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis. Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made. After G1, the cells enter S ...
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