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In 2001 the company acquired Biochem Canada. [9] Shire's next acquisition didn't come until 2005 when it acquired Transkaryotic Therapeutics [10] and two years later – in 2007 – New River Pharmaceuticals Inc, for a then company record of $2.6 billion. [11] With the purchase of New River, Shire gained access and ownership of Vyvanse.
Potassium iodide is a chemical compound, medication, and dietary supplement. [4] [5] It is a medication used for treating hyperthyroidism, in radiation emergencies, and for protecting the thyroid gland when certain types of radiopharmaceuticals are used. [6]
[16]: 1, 3 In their 2017 list that ranked Canada's top 100 richest people, Toronto-based Rob McEwen of McEwen Mining, ranked 100th with a net worth of C$875 million, while number 1 on the list—the Toronto-based Thomson family of Thomson Reuters—had a net worth of C$39.13 billion. [17]
Steroidogenesis.Trilostane inhibits 3β-HSD. Trilostane is a steroidogenesis inhibitor. [1] It is specifically an inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD). [1] [15] As a result of this action, trilostane blocks the conversion of Δ 5-3β-hydroxysteroids, including pregnenolone, 17α-hydroxypregnenolone, dehydroepiandrosterone (DHEA), and androstenediol, into Δ 4-3-ketosteroids ...
Trodusquemine is an aminosterol (polyamine steroid conjugate) that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. [1] The compound exhibits broad-spectrum antimicrobial activity [2] and numerous regenerative, neuroprotective, anti-atherosclerotic, antitumor, antiangiogenic, antiobesity, and anxiolytic properties. [3]
Originally created as the "Department of Health" in 1919—in the wake of the Spanish flu crisis [4] —what is known as Health Canada today was formed in 1993 from the former Health and Welfare Canada department (established in 1944), which split into two separate units; the other department being Human Resources and Labour Canada. [5]