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His experience in the areas of glucose-6-phosphate biochemistry, carbon dioxide fixation, hexokinase and phosphate studies led him to hypothesize cotransport of glucose along with sodium through the intestine. Pictured right is of Dr. Crane and his drawing of the cotransporter system he proposed in 1960, at the international meet on membrane ...
In August 1960, in Prague, Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. [3] Cotransport was the first ever proposal of flux coupling in biology and was the most important event concerning carbohydrate absorption in the 20th century. [4] [5]
In August 1960, in Prague, Robert K. Crane presented for the first time his discovery of the sodium-glucose cotransport as the mechanism for intestinal glucose absorption. [17] Crane's discovery of cotransport was the first-ever proposal of flux coupling in biology. [18] [19]
History provides many examples of notable diasporas. The Eurominority.eu map (the European Union) Peoples of the World includes some diasporas and underrepresented/stateless ethnic groups. [1] Note: the list below is not definitive and includes groups that have not been given significant historical attention.
Crane's discovery of cotransport was the first ever proposal of flux coupling in biology. [16] Crane in 1961 was the first to formulate the cotransport concept to explain active transport. Specifically, he proposed that the accumulation of glucose in the intestinal epithelium across the brush border membrane was [is] coupled to downhill Na+ ...
The NKCC1 isoform consists of about 1,200 amino acids, with about 500 amino acids residues giving rise to twelve hydrophobic transmembrane regions. [5] However, evidence of a shorter NKCC1 mRNA transcript (6.7 kb to 7-7.5 kb) in skeletal muscle cells gives support that further NKCC1 variants exists in a tissue-specific manner. [6]
These individuals display highly elevated bile salt levels in plasma, but without a clear phenotype. In areas of the world with a high prevalence of HBV, there are multiple individuals who carry the NTCP p.S267F polymorphism on both alleles; this makes NTCP inactive as a bile acid transporter, but provides protection against HBV infection. [12]
Painting of Bimbache of El Hierro by Leonardo Torriani, 1592 The San are the oldest inhabitants of Southern Africa. Indigenous communities, peoples, and nations are those which have a historical continuity with pre-invasion and pre-colonial societies that developed on their territories, and may consider themselves distinct from other sectors of the societies now prevailing on those territories ...