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Personal shielding against more energetic radiation such as gamma radiation is very difficult to achieve as the large mass of shielding material required to properly protect the entire body would make functional movement nearly impossible. For this, partial body shielding of radio-sensitive internal organs is the most viable protection strategy.
For decades, the main cellular target for radiation induced damage was thought to be the DNA molecule. [10] This view has been challenged by data indicating that in order to increase survival, the cells must protect their proteins, which in turn repair the damage in the DNA. [11]
Dsup (contraction of damage suppressor) is a DNA-associating protein, unique to the tardigrade, [1] that suppresses the occurrence of DNA breaks by radiation. [2] [3] When human HEK293 cells were engineered with Dsup proteins, they showed approximately 40% more tolerance against X-ray radiation.
Unprotected experiments in the U.S. in 1896 with an early X-ray tube (Crookes tube), when the dangers of radiation were largely unknown.[1]The history of radiation protection begins at the turn of the 19th and 20th centuries with the realization that ionizing radiation from natural and artificial sources can have harmful effects on living organisms.
Tumor cells in a hypoxic environment may be as much as 2 to 3 times more resistant to radiation damage than those in a normal oxygen environment. [5] Much research has been devoted to overcoming this problem including the use of high pressure oxygen tanks, blood substitutes that carry increased oxygen, hypoxic cell radiosensitizers such as ...
Radiation emitted by radioisotopes or radiation generators is utilized in therapy for cancer or benign lesions and also in interventional procedures using fluoroscopy. There has been a tremendous increase in the use of ionizing radiation in medicine during recent decades and health professionals and patients are concerned about the harmful ...