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Lamotrigine, sold under the brand name Lamictal among others, is a medication used to treat epilepsy and stabilize mood in bipolar disorder. [ 5 ] [ 8 ] For epilepsy, this includes focal seizures , tonic-clonic seizures , and seizures in Lennox-Gastaut syndrome . [ 8 ]
The WHO's definition is: "The DDD is the assumed average maintenance dose per day for a drug used for its main indication in adults." [ 1 ] The Defined Daily Dose was first developed in the late 1970s.
The maximum dose is used, rather than a lower dose, to reduce the number of test subjects (and, among other things, the cost of testing), to detect an effect that might occur only rarely. This type of analysis is also used in establishing chemical residue tolerances in foods. Maximum tolerated dose studies are also done in clinical trials.
In juvenile myoclonic epilepsy, it is a second-line therapy, reserved for when the valproates or lamotrigine do not work and when the other second-line therapy, acetazolamide, does not work. [14] The usual dose for seizure disorder is titrated from 100-125 mg/day up to a maintenance dose of 750-1,500 mg/day (maximum daily dosage is 2 g). [15]
Many older people living in long term care facilities experience polypharmacy, and under-prescribing of potentially indicated medicines and use of high risk medicines can also occur. [37] Medicine use rises from 6.0 ± 3.8 regular medicines on average when people enter long term care to 8.9 ± 4.1 regular medicines after two years. [39]
Multimorbidity is common in older adults, estimated to affect over half of those aged 65 and over. This increased prevalence has been explained by older adults' "longer exposure and increased vulnerability to risk factors for chronic health problems". [2] The prevalence of multimorbidity has been increasing in recent decades.
Each year, RSV infections cause about 177,000 hospitalizations and 14,000 deaths in adults aged 65 and older, per CDC data. It also leads to about 58,000 hospitalizations and 500 deaths in ...
MCI is a transitional state between normal aging and Dementia, affecting 10-20% of adults over 65 (Schwarz, 2015). Geriatricians encounter MCI patients in various care settings, with diagnosis relying on clinical assessment and mental status examinations (Tangalos & Petersen, 2018).