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RAS Mutations & Treatment Options
- Challenges In PDAC
PDAC Remains Highly Lethal
Current Treatment Falls Short
- Targeting RAS Mutations
Targeting RAS-Addicted PDAC
Targeting RAS Mutations
- Prevalence Of RAS
RAS Mutations In PDAC
Impact Over 90% Of PDAC Patients
- RAS Mutations
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FOLFIRINOX is a chemotherapy regimen for treatment of advanced pancreatic cancer.It is made up of the following four drugs: FOL – folinic acid (leucovorin), a vitamin B derivative that enhances the effects of 5-fluorouracil (5-FU); [1] [2]
Pancreatic cancer can be treated with surgery, radiotherapy, chemotherapy, palliative care, or a combination of these. [1] Treatment options are partly based on the cancer stage. [ 1 ] Surgery is the only treatment that can cure pancreatic adenocarcinoma, [ 12 ] and may also be done to improve quality of life without the potential for cure.
The Panova-3 trial enrolled 571 newly diagnosed pancreatic cancer patients with advanced-stage disease and randomized them to receive standard chemotherapy plus tumor-treating fields or just chemo.
HER2-positive breast cancer, gastric cancer, pancreatic cancer (orphan) and gastro-oesophageal junction cancer. Cardiac dysfunction, infusion-related reactions, peripheral neuropathy and pulmonary toxicity (rare). 2.2 Tyrosine kinase inhibitor: Afatinib: PO: EGFR, HER2 and HER4 inhibitor. Non-small cell lung cancer.
Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
A pancreatic tumor is an abnormal growth in the pancreas. [1] In adults, almost 90% are pancreatic cancer and a few are benign. [1] Pancreatic tumors are rare in children. [1] Classification is based on cellular differentiation (ductal, acinar, neuroendocrine, other) and gross appearance (intraductal, cystic, solid). [1]
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