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Citicoline , also known as cytidine diphosphate-choline (CDP-choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.
Structures and localization of the enzymes in the CDP-choline pathway. [1]: 415 The CDP-choline pathway, first identified by Eugene P. Kennedy in 1956, is the predominant mechanism by which mammalian cells synthesize phosphatidylcholine (PC) for incorporation into membranes or lipid-derived signalling molecules. [1] [2] The CDP-choline pathway ...
Choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction. CTP + choline phosphate diphosphate + CDP-choline. where the two substrates of this enzyme are CTP and choline phosphate, and the two products are diphosphate and CDP-choline. It is responsible for regulating phosphatidylcholine content in ...
alkylacylglycerol choline phosphotransferase, alkylacylglycerol cholinephosphotransferase, CDP-choline diglyceride phosphotransferase, cholinephosphotransferase, CPT, cytidine diphosphocholine glyceride transferase, cytidine diphosphorylcholine diglyceride transferase, diacylglycerol choline phosphotransferase, phosphocholine ...
Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene. [5] [6] [7] The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role.
CDP-diacylglycerol + choline CMP + phosphatidylcholine Thus, the two substrates of this enzyme are CDP-diacylglycerol and choline , whereas its two products are CMP and phosphatidylcholine . This enzyme belongs to the family of transferases , specifically those transferring non-standard substituted phosphate groups.