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Thus, Hedgehog pathway inhibitors are an important class of anti-cancer drugs. [10] [11] [12] At least three Hedgehog pathway inhibitors have been approved by the Food and Drug Administration (FDA) for cancer treatment. [12]
The Hedgehog signaling pathway is a signaling pathway that transmits information to embryonic cells required for proper cell differentiation. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include cancer ...
Curis and Roche Group 's Genentech unit have stopped a hedgehog -- not a spiky little beast, but a signaling pathway that could be the key in developing next-generation network-targeted cancer ...
Sonidegib , sold under the brand name Odomzo, is a medication used to treat cancer. [ 1 ] Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism).
Vismodegib, sold under the brand name Erivedge, is a medication used for the treatment of basal-cell carcinoma (BCC). [3] The approval of vismodegib on January 30, 2012, represents the first Hedgehog signaling pathway targeting agent to gain U.S. Food and Drug Administration (FDA) approval. [4]
It also is the target of vismodegib, the first hedgehog pathway inhibitor to be approved by the U.S. Food and Drug Administration (FDA). [8] Smoothened (Smo) is a key transmembrane protein that is a key component of the hedgehog signaling pathway, a cell-cell communication system critical for embryonic development and adult tissue homeostasis.