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PCR inhibitors are any factor which prevent the amplification of nucleic acids through the polymerase chain reaction (PCR). [1] PCR inhibition is the most common cause of amplification failure when sufficient copies of DNA are present. [2] PCR inhibitors usually affect PCR through interaction with DNA or interference with the DNA polymerase.
Classic DNA inhibitors such as the quinolones act upon DNA gyrase as a topoisomerase inhibitor. [2] Another group of DNA inhibitors, including nitrofurantoin and metronidazole, act upon anaerobic bacteria. [3] These act by generating metabolites that are incorporated into DNA strands, which then are more prone to breakage. [4] These drugs are ...
A hypomethylating agent (or demethylating agent [1]) is a drug that inhibits DNA methylation: the modification of DNA nucleotides by addition of a methyl group.Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, treatment with a hypomethylating agent is considered a type of epigenetic therapy.
DNA polymerase inhibitors (4 P) N. Nitrogen mustards (1 C, 41 P) T. Topoisomerase inhibitors (2 C, 38 P) Pages in category "DNA replication inhibitors"
To carry out gene expression, a cell must control the coiling and uncoiling of DNA around histones.This is accomplished with the assistance of histone acetyl transferases (HAT), which acetylate the lysine residues in core histones leading to a less compact and more transcriptionally active euchromatin, and, on the converse, the actions of histone deacetylases (HDAC), which remove the acetyl ...
How and why the drugs have such wide-ranging health benefits is subject to further research, and the GLP-1 drugs were found to increase risks of some conditions, including kidney stones and low ...
Dialkylating agents can react with two different 7-N-guanine residues, and, if these are in different strands of DNA, the result is cross-linkage of the DNA strands, which prevents uncoiling of the DNA double helix. If the two guanine residues are in the same strand, the result is called limpet attachment of the drug molecule to the DNA.
These topoisomerase-DNA-inhibitor complexes are cytotoxic agents, as the un-repaired single- and double stranded DNA breaks they cause can lead to apoptosis and cell death. [ 2 ] [ 3 ] Because of this ability to induce apoptosis, topoisomerase inhibitors have gained interest as therapeutics against infectious and cancerous cells.