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Chemotherapy-induced acral erythema, also known as palmar-plantar erythrodysesthesia or hand-foot syndrome is reddening, swelling, numbness and desquamation (skin sloughing or peeling) on palms of the hands and soles of the feet (and, occasionally, on the knees, elbows, and elsewhere) that can occur after chemotherapy in patients with cancer.
Epothilones cause microtubule disruption (like taxane-based drugs), which impairs axonal transport and leads to hyperexcitability of peripheral neurons. They can cause neuropathy characterized by paresthesias, numbness, and pain in the hands and feet.
A callus (pl.: calluses) is an area of thickened and sometimes hardened skin that forms as a response to repeated friction, pressure, or other irritation. Since repeated contact is required, calluses are most often found on the feet and hands, but they may occur anywhere on the skin. Some degree of callus, such as on the bottom of the foot, is ...
The best way to treat and prevent foot calluses involves at least three steps, according to our experts: physically exfoliate to remove dead skin, use a topical cream to further exfoliate and ...
For example, very curvy ear canals, narrow ear canals, or surgical ears are more prone to earwax buildup. When wax builds up, it causes muffled hearing, tinnitus, or aural fullness (plugged-up ...
Ototoxicity is defined as the toxic effect on the functioning of the inner ear, which may lead to temporary or permanent hearing loss (cochleotoxic) and balancing problems (vestibulotoxic). [1] Drugs or pharmaceutical agents inducing ototoxicity are regarded as ototoxic medications. Anatomy of the human ear
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The average middle ear volume is 0.4 mL, which limits otic accumulation in overdose. [6] It is unlikely that an cerumenolytic administered into the ear would cause systemic toxicity in an overdose situation, due to the lack of systemic absorption resulting from minimal volume flow within the inner ear. [7]