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Antimicrobial peptides have been used as therapeutic agents; their use is generally limited to intravenous administration or topical applications due to their short half-lives. As of January 2018 the following antimicrobial peptides were in clinical use: [29] Bacitracin for pneumonia, topical; Boceprevir, Hepatitis C (oral, cyclic peptide)
Bacitracin is a polypeptide antibiotic derived from a bacterium, Bacillus subtilis, and acts against bacteria through the inhibition of cell wall synthesis. [6] It does this by inhibiting the removal of phosphate from lipid compounds, thus deactivating its function to transport peptidoglycan; the main component of bacterial cell membranes, to the microbial cell wall.
Different peptides such as creatine peptides, collagen peptides, copper peptides and antimicrobial peptides each have various health benefits.
Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.
These peptides have organized pendant groups, making one side of the polymer hydrophobic and the other side cationic. [23] This group of polymers efficiently induce cell death through cell wall penetration. [1] Polymer mimics of these antimicrobial peptides have been developed. Protein-mimicking polymers emulate the structure of magainin and ...
Pages in category "Antimicrobial peptides" The following 54 pages are in this category, out of 54 total. This list may not reflect recent changes. ...
The name lantibiotics was introduced in 1988 as an abbreviation for "lanthionine-containing peptide antibiotics". [1] The first structures of these antimicrobial agents were produced by pioneering work by Gross and Morell in the late 1960s and early 1970s, thus marking the formal introduction of lantibiotics.
Structurally nanoengineered antimicrobial polypeptide polymers (SNAPPs) are a type of artificially designed synthetic antimicrobial peptide. The development of the polymers is potentially a treatment for bacterial diseases. [ 1 ]