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Exome sequencing workflow: part 1. Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). [1] It consists of two steps: the first step is to select only the subset of DNA that encodes proteins.
Prices are expected to drop further over the next few years through economies of scale and increased competition. [21] [22] As of 2014, nearly complete exome sequencing was offered by Gentle for less than $2,000, including personal counseling along with the results. [23]
The initial price was $50,000/person. One of the first clients was former Solexa CEO John West, who had his entire family of four sequenced. [22] In January 2012, Life Technologies unveiled a new sequencing instrument, the Ion Proton Sequencer, which it said would achieve the $1,000 genome in a day within 12 months. [23]
There are two methods to conduct DNA sequencing, Whole Exome Sequencing (WES) [2] and Whole Genome Sequencing (WGS). [6] Formal way of sequencing, the sanger technique had some limitations that it was costly and time-consuming. The recent development of Next Generation Sequencing (NGS) [7] dramatically remedied the shortcomings of Sanger ...
The price to sequence a genome at that time was $ ... [114] As of 2015, whole genome and exome sequencing as a newborn screening tool were deliberated [115] and in ...
DNA sequencing is the ... applies to exome sequencing, ... This technology provides intermediate read length and price per base compared to Sanger sequencing on one ...
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