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The inhibition of the phosphodiesterase would lead to a buildup of cAMP, increasing the activity of the second messenger throughout the cell. Though this mechanism is possible, it only occurs after levels of caffeine have reached a toxic level, and therefore it is unlikely to explain the mechanism of caffeine in the brain. [9]
This underlying cause is reversible if you quit the meds, but other reversible causes might not be so obvious. Depression or major stress could cause impairment to show up in testing, too, Boyle says.
A recent study observed changes in people's brain activity after they drank a cup of coffee that were not present in those who consumed caffeine on its own.
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The health effects of coffee include various possible health benefits and health risks. [1]A 2017 umbrella review of meta-analyses found that drinking coffee is generally safe within usual levels of intake and is more likely to improve health outcomes than to cause harm at doses of 3 or 4 cups of coffee daily.
Caffeine dependence can cause a host of physiological effects if caffeine consumption is not maintained. Withdrawal symptoms may include headaches, fatigue, difficulty concentrating, lack of motivation, mood swings, nausea, insomnia, dizziness, cardiac issues, hypertension, anxiety, backaches, and joint pain; these can range in severity from mild to severe. [18]
These symptoms including nervousness, irritability, restlessness, insomnia, headaches, and palpitations after caffeine use. [4] Caffeinism usually occurs when consumption of caffeine reaches 1–1.5 grams (0.035–0.053 oz) per day. [5] For reference, a brewed 8oz (227ml) cup of coffee contains ~95 mg of caffeine (per USDA). [6]
Why you should never drink caffeine on an empty stomach if you have anxiety.