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Indium-111 (111 In) is a radioactive isotope of indium (In). It decays by electron capture to stable cadmium-111 with a half-life of 2.8 days. [3] Indium-111 chloride (111 InCl) solution is produced by proton irradiation of a cadmium target (112 Cd(p,2n) or 111 Cd(p,n)) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA). [4]
The indium-111 pentetreotide radiopharmaceutical is prepared from a kit in a radiopharmacy. Pentetreotide is a DTPA conjugate of octreotide. [6] [11] Approximately 200 megabecquerels (MBq) of indium-111 is injected intravenously. Imaging takes place 24 hours after injection, but may also be carried out at 4 and 48 hours. [7] [12]
Indium (111 In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer. [1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. [2]
The spinal fluid is injected with a radiopharmaceutical tracer, such as DTPA tagged with indium 111, through a lumbar puncture. The tracer will diffuse up the spinal column and into the intracranial ventricles and the subarachnoid spaces around the brain.
Pendetide (GYK-DTPA) is a chelating agent. ... The following monoclonal antibodies are linked to pendetide to chelate a radionuclide, indium-111. The antibodies ...
Indium (111 In) satumomab pendetide (trade name OncoScint CR103) is a mouse monoclonal antibody which is used for cancer diagnosis. [1] The antibody, satumomab, is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111.
Typically technetium-99m sulphur colloid or DTPA is used. [4] [1] [5] Some studies may also involve a liquid component, which is labelled with indium-111 DTPA. [5] Images are acquired with a gamma camera, initially dynamically and then at intervals for up to 2-3 hours. [1] [5] [6]
Indium-111 is also used in indium white blood cell scans, which use nuclear medical techniques to search for hidden infections. Several proton-rich isotopes of indium (including indium-99) have been used to measure the mass of the doubly-magic isotope tin-100. [5] [6]