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The indium white blood cell scan is a nuclear medicine procedure in which white blood cells (mostly neutrophils) are removed from the patient, tagged with the radioisotope Indium-111, and then injected intravenously into the patient. The tagged leukocytes subsequently localize to areas of relatively new infection.
Indium-111 (111 In) is a radioactive isotope of indium (In). It decays by electron capture to stable cadmium-111 with a half-life of 2.8 days. [3] Indium-111 chloride (111 InCl) solution is produced by proton irradiation of a cadmium target (112 Cd(p,2n) or 111 Cd(p,n)) in a cyclotron, as recommended by International Atomic Energy Agency (IAEA). [4]
Indium-111 is also used in indium white blood cell scans, which use nuclear medical techniques to search for hidden infections. Several proton-rich isotopes of indium (including indium-99) have been used to measure the mass of the doubly-magic isotope tin-100. [5] [6]
Radioactive indium-111 (in very small amounts) is used in nuclear medicine tests, as a radiotracer to follow the movement of labeled proteins and white blood cells to diagnose different types of infection.
An excess of white blood cells is usually due to infection or inflammation. Less commonly, a high white blood cell count could indicate certain blood cancers or bone marrow disorders. The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important subset of the complete blood count.
Immunoscintigraphy is performed using a variety of radiopharmaceuticals, for a large range of purposes. Colorectal cancer is one of the most studied areas, with indium-111 or technetium-99m labelled epitopes of the carcinoembryonic antigen. [3]
The FDA determined that the data presented in a 2022 color additive petition show that this ingredient causes cancer in male laboratory rats exposed to high levels of FD&C Red No. 3 because of a ...
Leukocyte-promoting factor, more commonly known as leukopoietin, is a category of substances produced by neutrophils when they encounter a foreign antigen.Leukopoietin stimulates the bone marrow to increase the rate of leukopoiesis in order to replace the neutrophils that will inevitably be lost when they begin to phagocytose the foreign antigens.