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Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. [citation needed] Simvastatin had been shown to interact with lipid-lowering transcription factor PPAR-alpha [36] and that interaction might control the neurotrophic action of the drug.
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.
While there have been concerns about side-effects associated with statins (myopathy and rhabdomyolysis), these were rare in this study. [citation needed] The number needed to treat in the study was 57 to postpone one death and 19 to prevent one cardiovascular "event" (in those taking the drug simvastatin for 5 years). There was no mortality ...
There can be a genetic link for high cholesterol, but for the majority of us, lifestyle and diet will be the key deciding factors in how high it goes. ... 24/7 Help. For premium support please ...
LDL cholesterol is between 100 and 159. HDL cholesterol is between 40 and 59 for men, or 50 and 59 for women. Levels are high if: Total cholesterol is 240 or higher. LDL cholesterol is 160 or ...
But four medications were linked to a lower risk of mortality during the 12-year study period, including sildenafil (better known as Viagra), the cholesterol drug atorvastatin, the pain reliever ...