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Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.
Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening cases. Wider use is discouraged due to the significant side effects related to cholinergic excess including seizures, muscle weakness, bradycardia, bronchoconstriction, lacrimation, salivation, bronchorrhea, vomiting, and diarrhea.
Acetylcholine Acetylcholinesterase Acetylcholinesterase inhibition. Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, [1] inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, [2] thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ...
Common side effects of inhalant use include dry mouth, cough, inflammation of the airways, [3] and shortness of breath. [8] Potentially serious side effects include urinary retention, worsening spasms of the airways, and a severe allergic reaction. [3] It appears to be safe in pregnancy and breastfeeding.
Clofedanol or chlophedianol , sold under the brand name Ninjacof among others, is a centrally acting cough suppressant used in the treatment of dry cough. Clofedanol has local anesthetic, antispasmodic, and antihistamine properties, [1] and may have anticholinergic effects at high doses. [2]
Phenylpropanolamine (PPA), sold under many brand names, is a sympathomimetic agent used as a decongestant and appetite suppressant. [9] [1] [10] [11] It was once common in prescription and over-the-counter cough and cold preparations. The medication is taken orally. [4] [12] Side effects of phenylpropanolamine include increased heart rate and ...
Cough Drops 3-Pack. Halls is a trusted name in cough drops, and this three-pack has a little of everything to get yours under control. These drops contain menthol to help soothe your sore throat ...
In 1900, Reid Hunt, a pharmacologist (1870-1948), realised a fall in blood pressure in rabbits after removing adrenaline (epinephrine) from adrenal glands extract. While he initially attributed this effect to choline, he later discovered acetylcholine was 100 000 times more potent in lowering blood pressure.