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PZ-601 is a carbapenem antibiotic currently being tested as having a broad spectrum of activity including strains resistant to other carbapenems. Despite early Phase II promise, Novartis (who acquired PZ-601 in a merger deal with Protez Pharmaceuticals) recently dropped PZ-601, citing a high rate of adverse events in testing.
This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class. Antibiotics are listed alphabetically within their class or subclass by their nonproprietary name. If an antibiotic is a combination drug, both ingredients will be listed.
Pages in category "Carbapenem antibiotics" The following 18 pages are in this category, out of 18 total. This list may not reflect recent changes. ...
The following is a list of antibiotics. ... Certain carbapenems and carbapenem-beta-lactamase-inhibitors combinations: Carbapenems: (meropenem, ...
β-Lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a β-lactam ring in their chemical structure. This includes penicillin derivatives ( penams ), cephalosporins and cephamycins ( cephems ), monobactams , carbapenems [ 1 ] and carbacephems . [ 2 ]
Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections. [3] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.
Ertapenem, sold under the brand name Invanz, is a carbapenem antibiotic medication used for the treatment of infections of the abdomen, the lungs, the upper part of the female reproductive system, and the diabetic foot.
In general, carbapenem, a β-lactam antibiotic, targets cells by inhibiting transpeptidases (penicillin-binding proteins). This prevents synthesis of peptidoglycan, a necessary structural component, leading to cell lysis. Resistance to carbapenem among Enterobacteriaceae and other gram-negative bacteria can be acquired through several mechanisms.