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The drug is bound to albumin with high affinity, while α 1-acid glycoprotein and lipoproteins contribute much less to total plasma protein binding. [7] The unbound or free fraction of levocetirizine has been reported to be 8%. [7] The true volume of distribution of cetirizine is unknown but is estimated to be 0.3 to 0.45 L/kg.
Vitamin D supplementation during pregnancy may help to prevent gestational diabetes. [62] A 2015 review found that when done during pregnancy moderate physical exercise is effective for the prevention of gestational diabetes. [63] A 2014 review however did not find a significant effect. [64]
Cannabis use during pregnancy should be avoided. [80] There is no known safe dose of cannabis while pregnant and use of cannabis may lead to birth defects, pre-term birth, or low birth weight. [80] Tetrahydrocannabinol (THC), an active ingredient in cannabis, can both cross the placenta and accumulates in high concentrations in breast milk. [81]
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According to a study conducted by Whitcome, et al., lumbar lordosis can increase from an angle of 32 degrees at 0% fetal mass (i.e. non-pregnant women or very early in pregnancy) to 50 degrees at 100% fetal mass (very late in pregnancy). Postpartum, the angle of the lordosis declines and can reach the angle prior to pregnancy.
Determination of these values was based on a RDA of 2.4 μg/day for non-pregnant women plus what will be transferred to the fetus during pregnancy and what will be delivered in breast milk. [ 33 ] [ 34 ] However, looking at the same scientific evidence, the European Food Safety Authority (EFSA) sets adequate intake (AI) at 4.5 μg/day for ...
The pregnancy category of a medication is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. It does not include any risks conferred by pharmaceutical agents or their metabolites in breast milk. Every drug has specific information listed in its product literature.
In the first trimester (blastogenesis and early embryonic stages), the mother experiences a minimal weight gain (approximately 0.5-2 kilograms), while the embryo weighs only 6 grams. In the second trimester and third trimester (late embryonic and fetal stages), the fetus undergoes rapid weight growth and the weight increases to about 3000~4000 ...