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The San Antonio Contraceptive Study was a clinical research study published in 1971 about the side effects of oral contraceptives. Women coming to a clinic in San Antonio, Texas to prevent pregnancies were not told they were participating in a research study or receiving placebos. Ten of the women became pregnant while on placebos. [183] [184 ...
Unethical human experimentation. Unethical human experimentation is human experimentation that violates the principles of medical ethics. Such practices have included denying patients the right to informed consent, using pseudoscientific frameworks such as race science, and torturing people under the guise of research.
Scott Reuben (US), a former Professor of Anesthesiology at Tufts University, falsified and fabricated clinical trials involving painkiller medications. [164] [165] Reuben pleaded guilty in 2010 to one count of health care fraud and was sentenced to six months in prison. [166] As of 2023 Reuben has had 25 of his research publications retracted ...
This list is not limited to drugs that were ever approved by the FDA. Some of them (lumiracoxib, rimonabant, tolrestat, ximelagatran and ximelidine, for example) were approved to be marketed in Europe but had not yet been approved for marketing in the US, when side effects became clear and their developers pulled them from the market.
Psychosurgery. 1880s. Psychosurgery (also called neurosurgery for mental disorder) has a long history. During the 1960s and 1970s, it became the subject of increasing public concern and debate, culminating in the US with congressional hearings. Particularly controversial was the work of Harvard neurosurgeon Vernon Mark and psychiatrist Frank ...
The Tuskegee Study of Untreated Syphilis in the Negro Male[1] (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with ...
Henry Knowles Beecher (February 4, 1904 [1] – July 25, 1976 [2]) was a pioneering American anesthesiologist, medical ethicist, and investigator of the placebo effect at Harvard Medical School. An article by Beecher's in 1966 on unethical medical experimentation in the New England Journal of Medicine — "Ethics and Clinical Research" — was ...
Jesse Gelsinger (June 18, 1981 – September 17, 1999) was the first person publicly identified as having died in a clinical trial for gene therapy. Gelsinger suffered from ornithine transcarbamylase deficiency, an X-linked genetic disease of the liver, the symptoms of which include an inability to metabolize ammonia – a byproduct of protein ...