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  2. Deoxyribonuclease I - Wikipedia

    en.wikipedia.org/wiki/Deoxyribonuclease_I

    Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1. [5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides.

  3. Deoxyribonuclease - Wikipedia

    en.wikipedia.org/wiki/Deoxyribonuclease

    DNase I Structure: DNase I is a glycoprotein with a molecular weight of 30,000 Da and a carbohydrate chain of 8-10 residues attached to Asn18 (orange). [3] It is an 𝛼,𝛽-protein with two 6-stranded 𝛽-pleated sheets which form the core of the structure. [4] These two core sheets run parallel, and all others run antiparallel.

  4. DNase-Seq - Wikipedia

    en.wikipedia.org/wiki/DNase-Seq

    DNase-seq (DNase I hypersensitive sites sequencing) is a method in molecular biology used to identify the location of regulatory regions, based on the genome-wide sequencing of regions sensitive to cleavage by DNase I. [1] [2] [3] FAIRE-Seq is a successor of DNase-seq for the genome-wide identification of accessible DNA regions in the genome ...

  5. MNase-seq - Wikipedia

    en.wikipedia.org/wiki/MNase-seq

    At sufficient concentrations, DNase I is capable of digesting nucleosome-bound DNA to 10bp, whereas micrococcal nuclease cannot. [17] Additionally, DNase-seq is used to identify DHSs, which are regions of DNA that are hypersensitive to DNase treatment and are often indicative of regulatory regions (e.g. promoters or enhancers). [57]

  6. Ribonuclease - Wikipedia

    en.wikipedia.org/wiki/Ribonuclease

    Ribonuclease (commonly abbreviated RNase) is a type of nuclease that catalyzes the degradation of RNA into smaller components. Ribonucleases can be divided into endoribonucleases and exoribonucleases, and comprise several sub-classes within the EC 2.7 (for the phosphorolytic enzymes) and 3.1 (for the hydrolytic enzymes) classes of enzymes.

  7. DNase footprinting assay - Wikipedia

    en.wikipedia.org/wiki/DNase_footprinting_assay

    A DNase footprinting assay [1] is a DNA footprinting technique from molecular biology/biochemistry that detects DNA-protein interaction using the fact that a protein bound to DNA will often protect that DNA from enzymatic cleavage. This makes it possible to locate a protein binding site on a particular DNA molecule.

  8. Cancer warning labels on alcohol? It's not that simple.

    www.aol.com/news/cancer-warning-labels-alcohol...

    The country's top doctor wants a new warning added to alcohol that would alert drinkers about links to cancer, but don't expect cigarette-style warning labels any time soon. U.S. Surgeon General ...

  9. Hypersensitive site - Wikipedia

    en.wikipedia.org/wiki/Hypersensitive_site

    DNase I hypersensitive sites within chromatin [1]. In genetics a hypersensitive site is a short region of chromatin and is detected by its super sensitivity to cleavage by DNase I and other various nucleases (DNase II and micrococcal nucleases).