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  2. Effects of long-term benzodiazepine use - Wikipedia

    en.wikipedia.org/wiki/Effects_of_long-term...

    A publication asked in 1981 if lorazepam is more toxic than diazepam. [68] In a study in 1984, 20 patients having taken long-term benzodiazepines were submitted to brain CT scan examinations. Some scans appeared abnormal.

  3. Benzodiazepine use disorder - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine_use_disorder

    A 1985 study found that triazolam and temazepam maintained higher rates of self-injection in both human and animal subjects compared to a variety of other benzodiazepines (others examined: diazepam, lorazepam, oxazepam, flurazepam, alprazolam, chlordiazepoxide, clonazepam, nitrazepam, flunitrazepam, bromazepam, and clorazepate). [7]

  4. Lorazepam - Wikipedia

    en.wikipedia.org/wiki/Lorazepam

    0.5 mg tablets of the Ativan brand of lorazepam. Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. In medicinal form, it is mainly available as tablets and a solution for injection, but, in some locations, it is also available as a skin patch, an oral solution, and a sublingual tablet.

  5. Oxazepam - Wikipedia

    en.wikipedia.org/wiki/Oxazepam

    [5] [4] [28] It has been shown to suppress cortisol levels. [29] Oxazepam is the most slowly absorbed and has the slowest onset of action of all the common benzodiazepines according to one British study. [30] Oxazepam is an active metabolite formed during the breakdown of diazepam, nordazepam, and certain similar drugs.

  6. Delorazepam - Wikipedia

    en.wikipedia.org/wiki/Delorazepam

    Delorazepams potency is approximately equal to that of lorazepam, being ten times more potent by weight than diazepam (1 mg delorazepam = 1 mg lorazepam = 5 mg diazepam), [21] typical doses range from 0.5 mg - 2 mg. Treatment is generally initiated at 1 mg for healthy adults and 0.5 mg in pediatric and geriatric patients and patients with mild ...

  7. 1 million pills with fentanyl seized by DEA in Inglewood in ...

    www.aol.com/news/1-million-pills-fentanyl-seized...

    The drugs' street value could be $15 million to $20 million. ... Federal agents seized about 1 million pills containing fentanyl during a raid in Inglewood this month, the largest bust of fentanyl ...

  8. Benzodiazepine - Wikipedia

    en.wikipedia.org/wiki/Benzodiazepine

    Left: The 1,4-benzodiazepine ring system. Right: 5-phenyl-1H-benzo[e] [1,4]diazepin-2(3H)-one forms the skeleton of many of the most common benzodiazepine pharmaceuticals, such as diazepam (7-chloro-1-methyl substituted). A pharmacophore model of the benzodiazepine binding site on the GABA A receptor. [190]

  9. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.