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Horizontal gene transfer is the primary mechanism for the spread of antibiotic resistance in bacteria, [8] [5] [9] [10] and plays an important role in the evolution of bacteria that can degrade novel compounds such as human-created pesticides [11] and in the evolution, maintenance, and transmission of virulence. [12]
An example is the viral transfer of DNA from one bacterium to another and hence an example of horizontal gene transfer. [2] [3] [page needed] Transduction does not require physical contact between the cell donating the DNA and the cell receiving the DNA (which occurs in conjugation), and it is DNase resistant (transformation is susceptible to ...
Prophages are important agents of horizontal gene transfer, and are considered part of the mobilome. Genes are transferred via transduction as the prophage genome is imperfectly excised from the host chromosome and integrated into a new host (specialized transduction) or as fragments of host DNA are packaged into the phage particles and ...
Transformation is one of three forms of horizontal gene transfer that occur in nature among bacteria, in which DNA encoding for a trait passes from one bacterium to another and is integrated into the recipient genome by homologous recombination; the other two are transduction, carried out by means of a bacteriophage, and conjugation, in which a ...
This lateral gene transfer occurred also beyond the Darwinian threshold, after heredity or vertical gene transfer was established. [4] [5] "Sequence comparisons suggest recent horizontal transfer of many genes among diverse species including across the boundaries of phylogenetic "domains". Thus determining the phylogenetic history of a species ...
Bacteriophages are thought to contribute extensively to horizontal gene transfer in natural environments, principally via transduction, but also via transformation. [103] Metagenomics-based studies also have revealed that viromes from a variety of environments harbor antibiotic-resistance genes, including those that could confer multidrug ...
Comparison of typical phage (bacteriophage) infection and transduction (A) with typical GTA (gene transfer agent) production and transduction (B). Gene transfer agents (GTAs) are DNA-containing virus-like particles that are produced by some bacteria and archaea and mediate horizontal gene transfer. Different GTA types have originated ...
Pathogenicity islands (PAIs), as termed in 1990, are a distinct class of genomic islands acquired by microorganisms through horizontal gene transfer. [1] [2] Pathogenicity islands are found in both animal and plant pathogens. [2] Additionally, PAIs are found in both gram-positive and gram-negative bacteria. [2]