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Evert Gorter and François Grendel (Dutch physiologists) approached the discovery of our present model of the plasma membrane structure as a lipid bi-layer. They simply hypothesized that if the plasma membrane is a bi-layer , then the surface area of the mono-layer of lipids measured would be double the surface area of the plasma membrane.
The Davson–Danielli model (or paucimolecular model) was a model of the plasma membrane of a cell, proposed in 1935 by Hugh Davson and James Danielli.The model describes a phospholipid bilayer that lies between two layers of globular proteins, which is both trilaminar and lipoprotinious. [1]
Fluid mosaic model of a cell membrane. The fluid mosaic model explains various characteristics regarding the structure of functional cell membranes.According to this biological model, there is a lipid bilayer (two molecules thick layer consisting primarily of amphipathic phospholipids) in which protein molecules are embedded.
The modern view of the plasma membrane is of a fluid lipid bilayer that has protein components embedded within it. The structure of the membrane is now known in great detail, including 3D models of many of the hundreds of different proteins that are bound to the membrane.
With James Danielli he proposed a model for cell membrane structure which became known as the Davson-Danielli or "protein sandwich" model. In 1931 he married the society portrait painter Marjorie Heath with whom he had one daughter. He was a cousin of the renowned journalist and broadcaster, Alistair Cooke. [2]
He was famous for research on the structure and the permeability of cell membranes, developing a physical-chemical model in collaboration with the physiologist Hugh Davson. This became known as the Davson-Danielli [2] or "protein sandwich" model. He also carried out studies on the chemistry of enzymes and proteins and tried to construct an ...
Cross-sectional view of the structures that can be formed by phospholipids in an aqueous solution. A biological membrane, biomembrane or cell membrane is a selectively permeable membrane that separates the interior of a cell from the external environment or creates intracellular compartments by serving as a boundary between one part of the cell and another.
The actin-based membrane skeleton (MSK) meshwork is directly situated on the cytoplasmic surface of the plasma membrane. Membrane skeleton fence, or membrane skeleton corralling model, suggests that this meshwork is likely to partition the plasma membrane into many small compartments with regard to the lateral diffusion of membrane molecules.