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  2. Telomeres in the cell cycle - Wikipedia

    en.wikipedia.org/wiki/Telomeres_in_the_cell_cycle

    This problem makes eukaryotic cells unable to copy the last few bases on the 3' end of the template DNA strand, leading to chromosome—and, therefore, telomere—shortening every S phase. [2] Measurements of telomere lengths across cell types at various ages suggest that this gradual chromosome shortening results in a gradual reduction in ...

  3. Telomerase - Wikipedia

    en.wikipedia.org/wiki/Telomerase

    Another study found little evidence that, in humans, telomere length is a significant biomarker of normal aging with respect to important cognitive and physical abilities. [ 39 ] Some experiments have raised questions on whether telomerase can be used as an anti-aging therapy , namely, the fact that mice with elevated levels of telomerase have ...

  4. Telomere - Wikipedia

    en.wikipedia.org/wiki/Telomere

    Human chromosomes (grey) capped by telomeres (white). A telomere (/ ˈ t ɛ l ə m ɪər, ˈ t iː l ə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated with specialized proteins at the ends of linear chromosomes (see Sequences).

  5. Eukaryotic chromosome fine structure - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_chromosome_fine...

    Telomere: Used to maintain chromosomal integrity by capping off the ends of the linear chromosomes. This region is a microsatellite , but its function is more specific than a simple tandem repeat. Throughout the eukaryotic kingdom, the overall structure of chromosome ends is conserved and is characterized by the telomeric tract - a series of ...

  6. Relationship between telomeres and longevity - Wikipedia

    en.wikipedia.org/wiki/Relationship_between...

    Telomeres at the end of a chromosome. The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan and even human immortality. [1] [2] Telomeres are sequences at the ends of chromosomes that shorten with each cell division and determine the lifespan of ...

  7. Repeated sequence (DNA) - Wikipedia

    en.wikipedia.org/wiki/Repeated_sequence_(DNA)

    Recombination is important as a source of genetic diversity, as a mechanism for repairing damaged DNA, and a necessary step in the appropriate segregation of chromosomes in meiosis. [14] The presence of repeated sequence DNA makes it easier for areas of homology to align, thereby controlling when and where recombination occurs.

  8. Non-homologous end joining - Wikipedia

    en.wikipedia.org/wiki/Non-homologous_end_joining

    Telomeres are normally protected by a "cap" that prevents them from being recognized as double-strand breaks. Loss of capping proteins causes telomere shortening and inappropriate joining by NHEJ, producing dicentric chromosomes which are then pulled apart during mitosis. Paradoxically, some NHEJ proteins are involved in telomere capping.

  9. Prokaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Prokaryotic_DNA_replication

    Prokaryotic DNA Replication is the process by which a prokaryote duplicates its DNA into another copy that is passed on to daughter cells. [1] Although it is often studied in the model organism E. coli , other bacteria show many similarities. [ 2 ]