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[2] [7] A pregnancy is anembryonic if a transvaginal ultrasound reveals a sac with a mean gestational sac diameter (MGD) greater than 25 mm and no yolk sac, or an MGD >25 mm with no embryo. [9] A transabdominal ultrasound can be used to diagnose anembryonic pregnancy if a gestational sac can be identified, but is empty. [3]
The mean sac diameter [3] can effectively estimate the gestational age [4] between 5 and 6 weeks, with an accuracy of about +/- 5 days. [5] The yolk sac and embryo should be readily identifiable when the gestational sac reaches a certain size — a yolk sac should be seen when the gestational sac is 20mm and a fetal pole should be seen when the ...
A gestational sac can be reliably seen on transvaginal ultrasound by 5 weeks' gestational age (approximately 3 weeks after ovulation). The embryo should be seen by the time the gestational sac measures 25 mm, about five and a half weeks. [10]
There is a correlation between having a single yolk sac and having a single amniotic sac. [1] However, it is difficult to detect the number of yolk sacs, because the yolk sac disappears during embryogenesis. [1] Cord entanglement and compression generally progress slowly, allowing parents and medical caregivers to make decisions carefully. [4]
Absence of embryo with heartbeat 7–10 days after a scan that showed a gestational sac with a yolk sac. [110] [111] Absence of embryo at least 6 weeks after last menstrual period. [110] [111] Amniotic sac seen adjacent to yolk sac, and with no visible embryo. [110] [111] Yolk sac of more than 7 mm. [110] [111]
With obstetric ultrasonography the gestational sac (intrauterine fluid collection) can be visualized at 4.5 to 5 weeks gestation, the yolk sac at 5 to 6 weeks gestation, and fetal pole at 5.5 to 6 weeks gestation. Ultrasound is used to diagnose multiple gestation, which cannot be diagnosed based on the presence of hCG in urine or blood. [15]
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