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This type of reaction is also called a 1,2-nucleophilic addition. The stereochemistry of this type of nucleophilic attack is not an issue, when both alkyl substituents are dissimilar and there are not any other controlling issues such as chelation with a Lewis acid , the reaction product is a racemate .
Nucleophilic conjugate addition is a type of organic reaction. Ordinary nucleophilic additions or 1,2-nucleophilic additions deal mostly with additions to carbonyl compounds. Simple alkene compounds do not show 1,2 reactivity due to lack of polarity , unless the alkene is activated with special substituents .
The addition proceeds mainly via polar addition, in which the nucleophilic organolithium species attacks from the equatorial direction, and produces the axial alcohol. [36] Addition of lithium salts such as LiClO 4 can improve the stereoselectivity of the reaction. [37] LiClO4 increase selectivity of t BuLi
Nucleophilic addition to propargyl mesylates or tosylates is used to form allenylstannanes. [13] These compounds react similarly to allylstannanes to afford homopropargyl alcohols, and any of the three reaction modes described above can be used with this class of reagents as well. (9)
Note that if a Grignard reagent (such as RMgBr) is used, the reaction with an enone would instead proceed through a 1,2-addition. The 1,4-addition mechanism of cuprates to enones goes through the nucleophilic addition of the Cu(I) species at the beta-carbon of the alkene to form a Cu(III) intermediate, followed by reductive elimination of Cu(I ...
When chiral allylmetals are used for nucleophilic addition reaction to achiral aldehydes, the chirality of the newly generated alcohol carbon is determined by the chirality of the allymetal reagents (Figure 1). The chirality of the allymetals usually comes from the asymmetric ligands used.
The Mannich reaction starts with the nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff base. The Schiff base is an electrophile which reacts in a second step in an electrophilic addition with an enol formed from a carbonyl compound containing an acidic alpha-proton.
An addition reaction is the reverse of an elimination reaction, in which one molecule divides into two or more molecules. For instance, the hydration of an alkene to an alcohol is reversed by dehydration. There are two main types of polar addition reactions: electrophilic addition and nucleophilic addition.