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Both structures exhibit localized vesicles at the active sites, clustered receptors at the post-synaptic membrane, and glial cells that encapsulate the entire synaptic cleft. In terms of synaptogenesis, both synapses exhibit differentiation of the pre- and post-synaptic membranes following initial contact between the two cells.
When an axon of cell A is near enough to excite a cell B and repeatedly or persistently takes part in firing it, some growth process or metabolic change takes place in one or both cells such that A’s efficiency, as one of the cells firing B, is increased. [1]: 62 The theory is often summarized as "Neurons that fire together, wire together."
Some of the most pervading examples of this can be seen through the development of the visual cortex in addition to the acquisition of language as a result of developmental plasticity during the critical period. [8] [32] A lesser known example, however, remains the critical development of respiratory control during developmental periods. At ...
Neuroplasticity, also known as neural plasticity or just plasticity, is the ability of neural networks in the brain to change through growth and reorganization. . Neuroplasticity refers to the brain's ability to reorganize and rewire its neural connections, enabling it to adapt and function in ways that differ from
Lashley contributed to psychology and neuropsychology in a number of ways. First, his publication, Brain Mechanisms and Intelligence: A Quantitative Study of Injuries to the Brain (1929) found evidence to suggest the idea of localization was wrong and brought to life the idea that the brain and its multiple parts work together for memory and ...
Two molecular mechanisms for synaptic plasticity involve the NMDA and AMPA glutamate receptors. Opening of NMDA channels (which relates to the level of cellular depolarization) leads to a rise in post-synaptic Ca 2+ concentration and this has been linked to long-term potentiation, LTP (as well as to protein kinase activation); strong depolarization of the post-synaptic cell completely ...
Nerve growth factor (NGF), the prototypical growth factor, is a protein secreted by a neuron's target cell. NGF is critical for the survival and maintenance of sympathetic and sensory neurons. NGF is released from the target cells, binds to and activates its high affinity receptor TrkA on the neuron, and is internalized into the responsive neuron.
Functional specialization is the idea that functions are localized within the brain and can only be carried out by particular area(s) of the brain. [citation needed] Some tasks appear to work on the mass action principle, with lesions causing less drastic effects than would be expected if the tasks were localized within the brain.